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Search for Malaria in Infectious Diseases
Physician-authored summaries on the latest research on malaria, editorials on malaria, and perspectives on malaria - drawn from the top medical journals.
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You searched for: malaria in Infectious Diseases
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Deaths from Falciparum Malaria in the U.K.
- April 4, 2012
- Mary E. Wilson, MD
- Infectious Diseases
Among individuals with imported falciparum malaria, older age, delayed care, no chemoprophylaxis, and birth in Europe were associated with increased risk for death.- Reviewing:
- Checkley AM et al., BMJ 2012 Mar 27; 344:e2116.
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Malaria Deaths Still High Free
- February 15, 2012
- Mary E. Wilson, MD
- Infectious Diseases
Malaria deaths are decreasing, especially among children in Africa, but they may be substantially higher than WHO estimates.- Reviewing:
- Murray CJL et al., Lancet 2012 Feb 4; 379:413. Anonymous., Lancet 2012 Feb 4; 379:385.
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First-Trimester Malaria: Treatment and Outcomes Free
- December 14, 2011
- Mary E. Wilson, MD
- Infectious Diseases
Symptomatic and asymptomatic malaria infections during the first trimester of pregnancy were associated with miscarriage; treatment appeared to be safe.- Reviewing:
- McGready R et al., Lancet Infect Dis 2011 Dec 13;: Desai M and Dellicour S., Lancet Infect Dis 2011 Dec 13;:
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RTS,S/AS01 Vaccine Reduces Malaria Incidence by Half Free
- October 20, 2011
- Mary E. Wilson, MD
- Infectious Diseases
Initial results from a phase III trial show protection against clinical and severe malaria during the 12 months after vaccination in children aged 5 to 17 months.- Reviewing:
- The RTS,S Clinical Trials Partnership., N Engl J Med 2011 Oct 18;: White NJ., N Engl J Med 2011 Oct 18;:
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RTS,S Malaria Vaccine Administered with EPI Vaccines Is Efficacious
- October 19, 2011
- Mary E. Wilson, MD
- Infectious Diseases
Malaria vaccine administered with Expanded Program on Immunization vaccines was safe and had >50% efficacy at 19 months. A phase III trial is under way.- Reviewing:
- Asante KP et al., Lancet Infect Dis 2011 Oct; 11:741. Dicko A and Doumbo O., Lancet Infect Dis 2011 Oct; 11:722.
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Malaria Predisposes to Bacteremia
- September 28, 2011
- Mary E. Wilson, MD
- Infectious Diseases
In Kenya between 1999 and 2007, pediatric hospitalizations for malaria decreased significantly, and those for bacteremia decreased in parallel.- Reviewing:
- Scott JAG et al., Lancet 2011 Sep 7;: Obaro S and Greenwood B., Lancet 2011 Sep 7;:
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Efficacy of a Blood-Stage Malaria Vaccine
- September 14, 2011
- Larry M. Baddour, MD
- Infectious Diseases
The vaccine did not provide significant protection against clinical malaria but appeared to have strain-specific efficacy.- Reviewing:
- Thera MA et al., N Engl J Med 2011 Sep 15; 365:1004.
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Mobile Phone Text Messages Improve Malaria Treatment
- August 17, 2011
- Mary E. Wilson, MD
- Infectious Diseases
In rural Kenya, one-way communication of text-message reminders about pediatric malaria case management improved health workers' adherence to treatment guidelines.- Reviewing:
- Zurovac D et al., Lancet 2011 Aug 4;: Moonen B and Cohen JM., Lancet 2011 Aug 4;:
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Malaria Immunity Persists More Than 2 Years after Sporozoite Inoculation
- May 11, 2011
- Mary E. Wilson, MD
- Infectious Diseases
Volunteers previously immunized via sporozoite inoculation showed parasite-specific immunity on rechallenge.- Reviewing:
- Roestenberg M et al., Lancet 2011 Apr 25;: Greenwood B and Targett G., Lancet 2011 Apr 25;:
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Rapid Diagnostic Tests for Malaria in an Endemic Area Free
- January 5, 2011
- Mary E. Wilson, MD
- Infectious Diseases
Basing treatment decisions on the results of rapid diagnostic tests resulted in high adherence to national treatment guidelines.- Reviewing:
- Masanja MI et al., Am J Trop Med Hyg 2010 Dec; 83:1238.
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Artesunate for Severe Malaria in Africa? Free
- November 10, 2010
- Mary E. Wilson, MD
- Infectious Diseases
In African children with severe malaria, mortality was 22.5% lower with parenteral artesunate than with quinine.- Reviewing:
- Dondorp AM et al., Lancet 2010 Nov 8;: Shanks GD., Lancet 2010 Nov 8;:
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Should Quinine Be Used for Uncomplicated Malaria? Free
- August 12, 2009
- Daniel J. Diekema, MD, MS
- Infectious Diseases
Among Ugandan children with uncomplicated falciparum malaria, treatment failure was much more common with oral quinine than with artemether-lumefantrine.- Reviewing:
- Achan J et al., BMJ 2009 Jul 21; 339:b2763.
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Simian Malaria Infects Humans Free
- April 8, 2009
- Stephen G. Baum, MD
- Infectious Diseases
PCR testing revealed Plasmodium knowlesi as the cause of malaria in a traveler returning from the Philippines.- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2009 Mar 13; 58:229.
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Rectal Artesunate Before Clinic Visit in Severe Malaria
- December 24, 2008
- Mary E. Wilson, MD
- Infectious Diseases
In patients with severe malaria who cannot promptly receive injectable medications, prereferral rectal artesunate reduces deaths and disability.- Reviewing:
- Gomes MF et al., Lancet 2008 Dec 8;: von Seidlein L and Deen JL., Lancet 2008 Dec 8;:
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Promising Results from Malaria Vaccine Trials Free
- December 17, 2008
- Mary E. Wilson, MD
- Infectious Diseases
RTS,S malaria vaccine with the AS02D adjuvant didn’t interfere with routine infant vaccines; given with the AS01E adjuvant, it protected 56% of children against malaria.- Reviewing:
- Bejon P et al., N Engl J Med 2008 Dec 11; 359:2521. Abdulla S et al., N Engl J Med 2008 Dec 11; 359:2533.
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Treating Malaria in Areas with Multiple Plasmodium Species
- December 17, 2008
- Mary E. Wilson, MD
- Infectious Diseases
Drugs that are effective against falciparum malaria work poorly against vivax; treatment choices for vivax malaria are limited.- Reviewing:
- Karunajeewa HA et al., N Engl J Med 2008 Dec 11; 359:2545. Baird JK., N Engl J Med 2008 Dec 11; 359:2601.
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Malaria Interventions Work in Africa
- November 12, 2008
- Mary E. Wilson, MD
- Infectious Diseases
Substantial decreases in malaria transmission were documented at sites in The Gambia and coastal Kenya where multiple interventions were implemented.- Reviewing:
- Ceesay SJ et al., Lancet 2008 Nov 1; 372:1545. O’Meara WP et al., Lancet 2008 Nov 1; 372:1555. Byass P., Lancet 2008 Nov 1; 372:1523.
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Deforestation and Malaria Transmission
- October 8, 2008
- Mary E. Wilson, MD
- Infectious Diseases
Deforestation changes microclimates in ways that can speed parasite development in mosquitoes, which could enhance malaria transmission.- Reviewing:
- Afrane YA et al., Emerg Infect Dis 2008 Oct; 14:1533.
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Preventive Treatment of Malaria in Asymptomatic Children
- July 23, 2008
- Mary E. Wilson, MD
- Infectious Diseases
In western Kenya, intermittent preventive treatment of malaria in schoolchildren reduced anemia prevalence and improved cognitive function.- Reviewing:
- Clarke SE et al., Lancet 2008 Jul 12; 372:127.
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Escape from Malaria — The Pyruvate Kinase Connection Free
- April 16, 2008
- Larry M. Baddour, MD
- Infectious Diseases
Pyruvate kinase deficiency protects against Plasmodium falciparum infection in erythrocytes by two different mechanisms.- Reviewing:
- Ayi K et al., N Engl J Med 2008 Apr 24; 358:1805. Daily JP and Sabeti P., N Engl J Med 2008 Apr 24; 358:1855.
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