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Search for Antibiotic Resistance in Infectious Diseases
Physician-authored summaries on the latest research on antibiotic resistance, editorials on antibiotic resistance, and perspectives on antibiotic resistance - drawn from the top medical journals.
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You searched for: antibiotic resistance in Infectious Diseases
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Antibiotic Resistance — More Than 4 Million Years Old!
- April 25, 2012
- Thomas Glück, MD
- Infectious Diseases
Bacteria from a cave in New Mexico, isolated for more than 4 million years, showed resistance to 14 commercially available antibiotics.- Reviewing:
- Bhullar K et al., PLoS ONE 2012 Apr 11; 7:e34953.
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Transmission of Antibiotic-Resistance Genes by Bacteriophages Free
- November 9, 2011
- Thomas Glück, MD
- Infectious Diseases
Coliphage DNA isolated from cattle, pig, and poultry waste was found to harbor typical resistance genes in high concentrations.- Reviewing:
- Colomer-Lluch M et al., Antimicrob Agents Chemother 2011 Oct; 55:4908.
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Antibiotic Resistance Is Nothing New
- September 14, 2011
- Richard T. Ellison III, MD
- Infectious Diseases
Genes encoding resistance to several major classes of antibiotics were detected in 30,000-year-old permafrost sediments.- Reviewing:
- D'Costa VM et al., Nature 2011 Aug 31;:
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Selective Decontamination of the Digestive Tract and Subsequent Antibiotic Resistance
- March 17, 2010
- Neil M. Ampel, MD
- Infectious Diseases
In a randomized crossover trial, the prevalence of antibiotic resistance in intensive care units increased significantly after periods of selective decontamination.- Reviewing:
- Oostdijk EAN et al., Am J Respir Crit Care Med 2010 Mar 1; 181:452. Wunderink RG., Am J Respir Crit Care Med 2010 Mar 1; 181:426.
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Pneumococcal Resistance in the Post–Conjugate Vaccine Era
- January 24, 2007
- Daniel J. Diekema, MD, MS
- Infectious Diseases
Vaccine serotypes are being replaced by penicillin-resistant nonvaccine serotypes.- Reviewing:
- Hanage WP et al., J Infect Dis 2007 Feb 1; 195:347-52.
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TB Antibiotic Resistance and Growth Fitness
- July 26, 2006
- Bradley E. Britigan, MD
- Infectious Diseases
Mutations that confer antibiotic resistance in Mycobacterium tuberculosis without decreasing bacterial growth fitness may be selected for during human infection.- Reviewing:
- Gagneux S et al., Science 2006 Jun 30; 312:1944-6.
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Antibiotic Cycling May Not Reduce Resistance
- March 28, 2005
- Neil M. Ampel, MD
- Infectious Diseases
The increase in organisms resistant to multiple antibiotics is a growing problem worldwide. One strategy to limit resistance in hospitals is antibiotic cycling -- using . . .- Reviewing:
- Van Loon HJ et al., Am J Respir Crit Care Med 2005 Mar 1; 171:480-7.
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Pneumococcal Conjugate Vaccine Reduces Antibiotic Resistance
- October 8, 2004
- Neil M. Ampel, MD
- Infectious Diseases
Infections due to antibiotic-nonsusceptible pneumococci are on the rise worldwide. Reducing the incidence of invasive pneumococcal disease (IPD) is one way to tackle this problem. . . .- Reviewing:
- Talbot TR et al., Clin Infect Dis 2004 Sep 1; 39:641-8. Klugman KP., Clin Infect Dis 2004 Sep 1; 39:649-51.
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Gram-Positive Bacteria and Antibiotic Resistance in Commercial Poultry
- May 24, 2004
- Richard T. Ellison III, MD
- Infectious Diseases
A connection between antibiotic use in livestock and the emergence of antibiotic-resistant bacteria is well established. Seeking a better understanding of antibiotic resistance, researchers at . . .- Reviewing:
- Nandi S et al., Proc Natl Acad Sci U S A 2004 May 4; 101:7118-22.
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Antimicrobial Resistance in Isolates from Humans and Food Animals
- May 2, 2012
- Mary E. Wilson, MD
- Infectious Diseases
Prevalence of multidrug resistance in Escherichia coli increased from 7% to 64% during the 5-decade study period and was more frequent in animal than in human isolates.- Reviewing:
- Tadesse DA et al., Emerg Infect Dis 2012 May; 18:741.
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In-Feed Antibiotics and the Swine Intestinal Microbiome: Unintended Consequences
- February 1, 2012
- Richard T. Ellison III, MD
- Infectious Diseases
Just 14 days of low-dose oral antibiotics markedly increased the diversity and abundance of antibiotic-resistance genes.- Reviewing:
- Looft T et al., Proc Natl Acad Sci U S A 2012 Jan 17;:
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Predicting Antibiotic Resistance Using HCAP Criteria?
- November 19, 2008
- Daniel J. Diekema, MD, MS
- Infectious Diseases
In patients with pneumonia, a simple scoring system using criteria for healthcare-associated pneumonia predicts the risk for resistant bacteria.- Reviewing:
- Shorr AF et al., Arch Intern Med 2008 Nov 10; 168:2205.
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When to Prescribe a New Antibiotic
- July 26, 2006
- Richard T. Ellison III, MD
- Infectious Diseases
Mathematical modeling has identified particular situations in which early use of a new antibiotic could be beneficial.- Reviewing:
- Wang YC and Lipsitch M., Proc Natl Acad Sci U S A 2006 Jun 20; 103:9655-60.
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Hospital-Wide Antibiograms: Good Enough?
- July 12, 2006
- Daniel J. Diekema, MD, MS
- Infectious Diseases
Hospital-wide reports can mask between-unit differences large enough to affect empirical antibiotic choice.- Reviewing:
- Binkley S et al., Infect Control Hosp Epidemiol 2006 Jul; 27:682-7. Clinical and Laboratory Standards Institute., 2005;:
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Cycling vs. Mixing Antibiotic Therapy in the ICU
- March 10, 2006
- Thomas Glück, MD
- Infectious Diseases
In a comparison of two strategies to avoid increased antibiotic resistance in the ICU, neither was clearly a winner.- Reviewing:
- Martínez JA et al., Crit Care Med 2006 Feb; 34:329-36. Bonten MJM and Weinstein RA., Crit Care Med 2006 Feb; 34:549-51.
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Dirty Tales of Antibiotic Resistance
- February 24, 2006
- Bradley E. Britigan, MD
- Infectious Diseases
Multidrug resistance is common among antibiotic-producing soil actinomycetes, and these organisms are a possible reservoir for resistance in human pathogens.- Reviewing:
- D’Costa VM et al., Science 2006 Jan 20; 311:374-7.
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Integrons Are Spread by Cross-Transmission
- August 5, 2005
- Neil M. Ampel, MD
- Infectious Diseases
Integrons are mobile DNA elements that can capture and carry genes, including those that encode for antibiotic resistance. To ascertain the role of integrons in . . .- Reviewing:
- Nijssen S et al., Clin Infect Dis 2005 Jul 1; 41:1-9. Norrby SR., Clin Infect Dis 2005 Jul 1; 41:10-1.
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Antibiotic Resistance Reduces Efficacy of H. pylori Therapy
- October 27, 2003
- Neil M. Ampel, MD
- Infectious Diseases
Infection with Helicobacter pylori is associated with peptic ulcer disease, gastric cancer, and nonulcer dyspepsia. Antacid therapy plus antibiotics is recommended for treatment. However, antibiotic . . .- Reviewing:
- Wong WM et al., Clin Infect Dis 2003 Oct 1; 37:882-9.
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Gram-Negative Antibiotic Resistance: News from the Front
- November 1, 1999
- B Britigan
- Infectious Diseases
Successful treatment of gram-negative bacteremia is being challenged by increasing antibiotic resistance, the extent of which varies by region. Ongoing monitoring of these trends in . . .- Reviewing:
- Diekema DJ et al., Clin Infect Dis 1999 Sep; 29:
595 607 .
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Antibiotic Resistance Increasing in Urinary Tract Pathogens
- April 1, 1999
- R Ellison
- Infectious Diseases
Because uncomplicated cystitis in women is caused by a limited number of microbial pathogens, with presumably predictable antibiotic susceptibility, urine cultures are often not performed . . .- Reviewing:
- Gupta K et al., JAMA 1999 Feb 24; 281:
736 738 .
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